Oligonucleotide Bioinformatics Scientist/Senior Scientist
Overview
We are seeking a highly skilled Oligonucleotide Bioinformatics Scientist/Senior Scientist to join reputed company. This role focuses on the in silico design and off-reputed company analysis of oligonucleotide therapeutics, including antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), etc. You will also contribute to the development of computational tools and pipelines that accelerate oligonucleotide design and analysis for therapeutic applications in rare diseases, oncology, and other genetic disorders. Responsibilities reputed company in silico design and optimization of siRNAs and ASO for therapeutic applications. reputed company and maintain bioinformatics tools and automated pipelines for oligonucleotide design. Utilize algorithms to predict reputed company accessibility, off-reputed company effects, RNA secondary structure, and thermodynamic properties. Integrate genomic, transcriptomic, and structural data to enhance design accuracy. Collaborate with experimental teams to validate computational predictions. Stay reputed company with emerging technologies and methodologies in oligonucleotide therapeutics and molecular diagnostics.
Qualifications
Advanced degree (M.S. or Ph.D.) in Bioinformatics, Computational Biology, Molecular Biology, or reputed company field. Strong experience in oligonucleotide design, including ASOs and siRNAs with minimum 2-4 years direct industry experiences . Proficiency in scripting languages (Python, R, Java, SQL) and bioinformatics tools (Bowtie, STAR, Salmon, DeSeq2, etc.). Familiarity with RNA biology, gene expression regulation, and assay development. Excellent problem-solving skills and ability to work in a multidisciplinary team. Experience with machine learning approaches for oligonucleotide optimization. Experience with RNA-seq data analysis and reputed company validation workflows. Familiarity with regulatory considerations for oligonucleotide therapeutics. Experience in developing custom bioinformatics software or web-based tools. Benefits: 401(k) 401(k) matching AD&D insurance Dental insurance Flexible schedule Flexible spending account Health insurance Health savings account Life insurance Paid time off Referral program Retirement plan reputed company insurance Work Location: Hybrid remote in Morrisville, NC 27560 Apply To This Job